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Active Ingredient:

• Nelarabine — a cytotoxic antineoplastic agent (5 mg/mL; total 250 mg per 50 mL vial).

Dosage Form & Strength:

• Clear, colorless, sterile solution in a single-dose vial.

• Each mL contains 5 mg of nelarabine in water for injection with sodium chloride and pH adjusters.

• Total volume: 50 mL per vial.

• Concentration: 5 mg/mL.

• Packaging: Single-dose glass vial — do not use if cloudy or particulate visible.

Mechanism of Action:

• Nelarabine is a pro-drug of a deoxyguanosine analogue (ara-G).

• Inside cells it’s converted to its active form that interferes with DNA synthesis, resulting in cancer cell death, especially in T-cell malignancies.

Indications / Therapeutic Use:

• Used for treatment of T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL).

• Typically given to patients whose disease has not responded to, or has relapsed after, prior chemotherapy regimens.