P.B.P Enterprises Private Limited

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 Injection is used in the treatment of leukemia(cancer of white blood cells). It is used for patients with leukemia who have not responded to other therapies. It is used alone or in combination with other medicine as first line therapy.

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Active Ingredient:

• Gemcitabine (1 g per vial) — a pyrimidine nucleoside analogue antimetabolite used in chemotherapy.

Dosage Form:

• Powder for concentrate for solution for infusion (to be reconstituted and diluted before administration).

Strength:

• 1000 mg per vial (equivalent to 1 g gemcitabine hydrochloride).

Appearance:

• Powder in sterile vial for reconstitution into a clear solution for intravenous infusion.

Gemcitabine works by interfering with DNA synthesis and inhibiting the replication of rapidly dividing cancer cells. It incorporates into DNA during the S-phase of the cell cycle, leading to cell death and tumor growth inhibition.

Gemcitabine 1000 mg is used (often in combination with other chemotherapy agents) in the treatment of:

• Non-small cell lung cancer (NSCLC)

• Pancreatic cancer

• Breast cancer

• Ovarian cancer

• Bladder cancer
  These indications depend on specific cancer type and treatment protocols.

• Route: Intravenous (IV) infusion only — administered by a qualified healthcare professional in a hospital or chemotherapy clinic.

• Infusion time: Typically over ~30 minutes per dose.

• Dose and schedule: Determined by the doctor based on cancer type, body surface area, blood counts, and treatment plan. Typical schedules involve dosing on specific days of a cycle (e.g., Days 1 and 8 of each cycle).

• Hypersensitivity: Do not use if allergic to gemcitabine or formulation components.

• Pregnancy & breastfeeding: Should be avoided unless clearly necessary; may cause fetal harm.

• Blood counts: Requires monitoring due to risk of low white cells, platelets, and red cells.

• Organ function: Caution in patients with liver or kidney impairment.

• Contraception: Effective contraception recommended during and after treatment (e.g., up to 6 months for men).

Some of the frequently seen adverse effects may include:

• Hematologic toxicity: neutropenia, thrombocytopenia, anemia (low blood cells)

• Gastrointestinal: nausea, vomiting, diarrhea

• Hair loss (alopecia) and fatigue

• Flu-like symptoms, fever

• Skin rash or swelling

• Respiratory effects (e.g., shortness of breath).

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• Metastatic colorectal (colon and rectum) cancer

• Non-small cell lung cancer (advanced)

• Renal (kidney) cell carcinoma

• Ovarian and fallopian tube cancers

• Cervical cancer

• Certain brain tumors such as glioblastoma
  (Final indication and regimen should be based on physician prescription and clinical guidelines.)

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Filgrastim injection is used to treat neutropenia (low white blood cells) that is caused by cancer medicines. It is a synthetic (man-made) form of a substance that is naturally produced in your body called a colony stimulating factor. Filgrastim helps the bone marrow to make new white blood cells.

Aprifast IV Injection is a prescription medicine used to prevent nausea and vomiting caused by chemotherapy.

Aprifast IV Injection is given under the supervision of healthcare professional. Moreover, it is better to take it at a fixed time and you should not stop taking this medication suddenly without talking to your doctor. In case you have missed a dose than it is better to take it as soon as you remember it and finish the full course of treatment even if you feel better. Your doctor may advice for regular monitoring of liver function test while taking this medicine.